Why do transgender people take spironolactone? Typically, you’ll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. This blocks male sex hormone (androgen) receptors and can suppress testosterone production.

Is spironolactone used for transitioning? Spironolactone is the most commonly prescribed anti-androgen (male hormone suppressant) for transgender women as part of their hormone therapy in the United States and Canada.

How quickly does spironolactone work MTF? The clinical benefits of spironolactone as a diuretic are typically not seen until 2–3 days after dosing begins. Likewise, the maximal antihypertensive effect may not be seen for 2–3 weeks.

How long should I take spironolactone for transitioning? It would take about 6 months of daily use to see any improvement/change. Spironolactone differs from finasteride which works at the level of DHT. I recommend you see a hair restoration specialist to follow you through this transition.

Why do transgender people take spironolactone? – Additional Questions

Does spironolactone make your breasts bigger?

Enlarged breasts: This drug may cause you to have enlarged breasts (gynecomastia). This can happen in both men and women. If this happens, your doctor may stop your treatment with this drug.

Is spironolactone safe MTF?

Spironolactone. Evidence suggests that spironolactone is a very safe way to lower testosterone. However, as spironolactone is a diuretic (water pill), using it as a testosterone blocker may cause some transgender women to urinate frequently.

Are the effects of spironolactone reversible?

Generally, the effects are reversible after discontinuation of the drug. Spironolactone induces gynecomastia by blocking androgen production, by blocking androgens from binding to their receptors, and by increasing both total and free estrogen levels.

Is 150 mg of spironolactone too much?

Adults should never take more than 400 mg of spironolactone per day or give more than 100 mg per day to children. Too much spironolactone can cause a drop in blood pressure from sitting to standing (postural hypotension), which can cause dizziness, lightheadedness, or fainting.

Can you stop spironolactone cold turkey?

Can you stop taking it ‘cold turkey’? You shouldn’t stop taking spironolactone without first talking with your doctor. Stopping this medication suddenly won’t cause withdrawal symptoms. But when you stop taking spironolactone it will quickly stop working to manage your condition.